By Steven Clarke (auth.), Ronald T. Borchardt, Cyrus R. Creveling, Per Magne Ueland (eds.)

This publication has been constructed from its past and much much less formal presentment because the court cases of a symposium entitled The Biochemistry of S-Adenosylmethionine as a foundation for Drug layout that was once held on the Solstrand Fjord lodge in Bergen, Norway on June 30-July four, 1985. the aim of the symposium was once to assemble scientists from a number of disciplines (biochemistry, pharmacology, virology, immunology, chemistry, medication, etc) to debate the hot advances which were made in our realizing of the organic roles of S­ adenosylmethionine (AdoMet) and to debate the feasibility of using AdoMet-dependent enzymes as ambitions for drug layout. therefore the knowledge supplied herein may be of worth not just to simple scientists occupied with elucidating the position of AdoMet in biology, but additionally to medicinal chemists who're utilizing this simple wisdom within the means of drug layout. the quantity must also be of curiosity to pharmacologists and clinicians fascinated about organic review of power healing brokers bobbing up from the efforts of the biochemists and medicinal chemists. each one plenary speaker on the symposium was once asked to post a bankruptcy reviewing fresh contributions in their self-discipline to our base of data in regards to the organic position of AdoMet. themes lined during this quantity comprise protein and phospholipid methylations (Section A), nucleic acid methyl­ ations (Section B), the rules of AdoMet, S-adenosylhomocysteine, and methylthioadenosine metabolism (Section C), medical points of AdoMet (Section D), and the layout, synthesis, and organic overview of trans­ methylation inhibitors (Section E).

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